Roberto Amadio

This study shows that the Arp2/3 complex is essential for genome integrity and survival of epidermal Langerhans cells, with Arpc4 deficiency leading to DNA damage and premature aging-like decline.

This study shows that WASp in macrophages prevents inflammation by maintaining nuclear integrity under mechanical stress, linking mechano-sensing to inflammatory responses.

The paper shows that ALCAM-mediated synapses between DC1 and CD8 T cells decrease in advanced lung tumors, impairing immune responses.

This study shows TIM4 enables large peritoneal macrophages to cross-present tumor antigens early in tumorigenesis, promoting CD8 T cell activation and immune surveillance.

The paper shows that DC-based therapy enhances CD8 T cell responses to neoantigens in lung tumors, particularly in high TMB tumors.