Author

Masoud Shirali

University of EdinburghORCID 0000-0002-5401-0541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:fine-mapping· 2 Research Focus:drug response / drug discovery· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Andrew Mark McIntoshiD· 3 shared Cathryn M. LewisiD· 3 shared David M. HowardiD· 3 shared Gail DaviesiD· 3 shared Ian J. DearyiD· 3 shared Mark J. AdamsiD· 3 shared Riccardo Emilio MarioniiD· 3 shared Saskia P. HagenaarsiD· 3 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Andrew Mark McIntoshORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintApr 11, 2019

Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics

Ning Zheng, Yakov A. Tsepilov, Sodbo Sharapov…·Xia Shen

This paper develops a multi-trait framework for discovering, replicating, and interpreting pleiotropic loci using GWAS summary statistics, identifying novel genetic associations without additional genotyping.

8 citations

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsNature NeurosciencePeer-reviewedFeb 4, 2019

✦ In-depth digest

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

David M. Howard, Mark J. Adams, Toni‐Kim Clarke…·Andrew Mark McIntosh

A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.

2,565 citationstop 1%

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsNature CommunicationsPeer-reviewedApr 11, 2018

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

David M. Howard, Mark J. Adams, Masoud Shirali…·Andrew Mark McIntosh

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

612 citationstop 1%

humanGWAS summary statistics

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GeneticsNature GeneticsPeer-reviewedDec 15, 2017

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

Michelle Luciano A, Saskia P. Hagenaars, Gail Davies…·Ian J. Deary

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

391 citationstop 1%

humanGWAS summary statistics

𝕏 PostBluesky