Merav Hecht

The paper identifies average polycomb CpG methylation as a hallmark of cellular aging using single-cell whole-genome methylation data, showing cell-to-cell variability and accelerated aging in faster proliferating cells.

This study identifies a CTCF-binding insulator element that regulates receptor editing and B-cell tolerance by controlling chromatin loop extrusion and Ig{lambda} development.

This study identifies three regulatory subtypes of lung neuroendocrine tumors through ChIP-seq and RNA-seq, revealing distinct transcription factor signatures and therapeutic vulnerabilities.

This study shows SMCHD1 loss causes DUX4 expression in FSHD2 by disrupting splicing of DNMT3B, leading to hypomethylation and muscle abnormalities.

The paper constructs a human DNA methylation atlas using whole-genome bisulfite sequencing of 39 cell types, revealing cell type-specific methylation patterns and regulatory elements.