Author

Thomas Chris Smits

Radboud University Medical CenterORCID 0000-0002-5486-9890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

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Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ankur AnkaniD· 1 shared Franka BuytenhuijsiD· 1 shared Johannes C. TextoriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Ankur AnkanORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintMar 28, 2025

Differential T cell receptor clonotype abundance analysis with similarity-based counts weighting

Franka Buytenhuijs, Thomas Chris Smits, Ankur Ankan, Johannes C. Textor

The paper introduces a pre-processing method for TCR-seq data using sequence similarity-based weighting to improve differential abundance analysis and reduce false positives.

DOI 10.1101/2025.03.28.645951

scRNA-seqstatistical model

𝕏 PostBluesky