João V. Rodrigues

The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.

This paper introduces Chroma, a generative model for proteins that can sample novel structures and sequences, conditioned on desired properties and functions.

This study combines machine learning with metabolic and structural analysis to identify specific drug targets from metabolomics data, using a case study of a DHFR-targeting antibiotic.

The paper investigates how proteostasis machinery influences higher-order epistasis in antibiotic resistance traits across different bacterial species.