BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
MRP1 inhibition by lipid-derived electrophiles during ferroptosis illustrates a role for protein alkylation in ferroptotic cell death
Antonius T. M. Van Kessel, Gonzalo Cosa
This study shows that lipid-derived electrophiles (LDEs) inhibit MRP1 activity during ferroptosis, linking LDE-mediated protein alkylation to cell death.