Michael H. Herschl

The paper introduces COMBINE, a platform that screens epigenetic effector domain pairs to identify synergistic and antagonistic interactions, revealing new mechanisms for transcriptional regulation.

The paper introduces a framework for designing cell-type-specific promoters using model-based optimization, demonstrating improved specificity in blood cancer cell lines.

This paper develops transfer learning strategies to model promoter-driven gene expression in understudied cell types, showing improvements in performance with pretraining and transfer.

The paper studies how gene silencing and reactivation spread between neighboring genes in single cells, finding different dynamics based on chromatin regulators and insulator elements.