BioengineeringbioRxivPreprint
Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery
John Paul Murad, Lea Christian, Reginaldo Cruz Alves Rosa…·Saul J. Priceman
This study engineers CAR T cells with PDL1-IL12 fusion proteins to enhance anti-tumor responses in solid tumors by improving T cell function and reducing systemic inflammation.
DOI 10.1101/2025.04.04.647304