Author

Tomáš Ruml

University of Chemistry and Technology, PragueORCID 0000-0002-5698-4366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Jan PrchaliD· 2 shared Alžběta DostálkováiD· 1 shared Aneta PagáčováiD· 1 shared Anna KlimešováiD· 1 shared Anna Pavlů· 1 shared Jakub SýsiD· 1 shared Klára Kušková· 1 shared Lucie Prokopová· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jan PrchalORCID

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2 papers

Recent·Most cited

BiochemistryProtein SciencePeer-reviewedAug 15, 2024

Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase

Matěj Danda, Anna Klimešová, Klára Kušková…·Michaela Rumlová

This study examines the phenotypic effects of mutations in SARS-CoV-2 RdRp subunits using biochemical assays, finding that some mutations alter enzyme stability, complex assembly, and activity, with implications for antiviral resistance.

3 citations

virusproteomics

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Molecular BiologyeLifePeer-reviewedMar 22, 2024

A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein

Markéta Častorálová, Jakub Sýs, Jan Prchal…·Tomáš Ruml

The paper shows that myristoyl exposure in M-PMV matrix protein triggers structural changes leading to efficient cleavage of Gag polyprotein.

7 citations

experimental assay

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