Cancer BiologybioRxivPreprint
A computational model of the spatiotemporal adaptation of tumor cells metabolism in a growing spheroid
Pierre Jacquet, Angélique Stéphanou
This paper develops a computational model to simulate tumor spheroid metabolism, revealing spatiotemporal metabolic diversity and the role of acidity and pyruvate-lactate interactions in shaping tumor cell behavior.
DOI 10.1101/2023.09.11.557115