Sarah R. Ball

This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.

This study reveals that lipids promote α-synuclein aggregation by enabling elongation, using a kinetic model to describe the co-aggregation process in vitro.

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.