Genetic & Genomic MedicinemedRxivPreprint
Endophenotype-Informed Polygenic Risk Stratification for Primary Open-Angle Glaucoma in individuals of African Ancestry
Aude Benigne Ikuzwe Sindikubwabo, Lannawill Caruth, Yan Zhu…·Shefali Setia-Verma
This paper develops endophenotype-informed polygenic risk scores for POAG in African ancestry individuals, showing improved clinical interpretability and risk stratification compared to aggregate scores.
DOI 10.1101/2025.09.29.25336758