Joachim Oskar Rädler

Disruption of KEA-mediated chloroplast ion homeostasis in Chlamydomonas reinhardtii reveals conserved and lineage-specific control of plastid rRNA processing and cell cycle progression.

This paper uses simulation-based inference to estimate cell-mechanical parameters from 1D cell trajectories, demonstrating its effectiveness in analyzing breast cell lines and drug effects.

This study investigates how buffer type affects lipid nanoparticle structure and transfection efficiency, finding citrate buffer enhances mRNA expression through altered phase transitions.

The paper shows that slow-codon windows reduce mRNA lifetime but not stability under RNA interference in human cells.

This study shows that miR-200c expression reduces metastasis in vivo and inhibits cell migration in vitro in breast cancer models.

This study investigates how nuclear deformation and forces change in migrating cells under 3D confinement, revealing a shift from pulling to pushing mechanisms as channel width decreases.

The paper investigates the relationship between mRNA delivery timing and protein expression in lipid-based transfection, finding no intrinsic correlation at the single-cell level.

This paper integrates single-cell perturbation experiments using nonlinear mixed effect modeling to robustly reconstruct cell-to-cell variability and improve parameter estimates.