Author

Alaa Shaikhqasem

Martin Luther University Halle-WittenbergORCID 0000-0002-5879-5585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. ParthieriD· 2 shared Constanze Breithaupt· 2 shared Farzad HamdiiD· 2 shared Fotis L. KyrilisiD· 2 shared Lisa Machner· 2 shared Milton T. StubbsiD· 2 shared Panagiotis L. KastritisiD· 2 shared Stephan M. FelleriD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

C. ParthierORCID

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2 papers

Recent·Most cited

BiochemistryStructurePeer-reviewedDec 22, 2025

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

Lisa Machner, Alaa Shaikhqasem, Tobias Gruber…·Milton T. Stubbs

This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.

6 citations

experimental assayprotein folding & dynamics

𝕏 PostBluesky

BiochemistryActa Crystallographica Section D Structural BiologyPeer-reviewedDec 15, 2025

Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals

Alaa Shaikhqasem, Farzad Hamdi, Lisa Machner…·Milton T. Stubbs

This paper introduces a method to reduce radiation damage and improve data completeness in 3D electron diffraction by using multi-position acquisition from multiple crystals.

3 citations

electronic health recordsexperimental assay

𝕏 PostBluesky