Li-Peng Hu

The paper shows that sympathetic norepinephrine in tumor-draining lymph nodes modifies GZMB in CD8 T cells to enhance cytotoxicity and improve tumor control.

The paper introduces a DNA nanostructure-based platform for single-base RNA mutation detection in living cells, demonstrating its ability to distinguish insulin mRNAs and detect KRASG12D mutations with high specificity.

This study shows citalopram reduces hepatocellular carcinoma by modulating C5aR1+ tumor-associated macrophages and enhancing CD8+ T cell anti-tumor immunity.

The paper shows pancreatic islets actively shape sympathetic innervation, with Reg2 and Reg3β promoting nerve regeneration and islet function.

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

This study identifies CLIC1 as a key molecule linking matrix stiffness and the Warburg effect in pancreatic cancer, promoting tumor growth through ROS/HIF1 signaling.

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.