Author
Brigham and Women's HospitalORCID 0000-0002-6187-1366Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jun Liu, Ziyang Shen, Shin‐Young Park…·Li Chai
This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.
Bee Hui Liu, Miao Liu, Radhakrishnan Sridhar…·Li Chai
This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.
Yanjing V. Liu, Mahmoud Adel Bassal, Migara Kavishka Jayasinghe…·Daniel Geoffrey Tenen
CRISPR-DiR induces locus-specific demethylation and chromatin remodeling to reactivate the p16 gene.
Junyu Yang, Chong Gao, Miao Liu…·LI Chai
This study shows that SALL4 can be induced in cancer cells to make them dependent on it, enabling targeted therapy with drugs like DAC and ENT.