Silviu Sbiera

This paper identifies DLK1 as a marker of adrenocortical stem/progenitor cells that predicts malignancy in adrenocortical carcinoma and is detectable in patient serum.

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

This study uses single-nuclei RNA sequencing to analyze adrenocortical carcinoma and identifies distinct cell populations associated with different tumor aggressiveness and molecular features.