Barbara Altieri

This paper identifies DLK1 as a marker of adrenocortical stem/progenitor cells that predicts malignancy in adrenocortical carcinoma and is detectable in patient serum.

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

This study identifies SOX2+ sustentacular cells as stem cells for postnatal adrenal medulla chromaffin cells, showing their ability to generate both adrenaline and noradrenaline lineages and maintain homeostasis via WNT6 secretion.

This study uses single-nuclei RNA sequencing to analyze adrenocortical carcinoma and identifies distinct cell populations associated with different tumor aggressiveness and molecular features.