Anne Couvelard

The paper identifies distinct progression paths in pancreatic papillary cystic neoplasms using integrated transcriptomics and histology, enabling phenotype-specific prediction of high-grade dysplasia.

This study shows that loss of HNF1B contributes to IPMN initiation and identifies its role as a tumor suppressor in pancreatic ductal cells.

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.