Author

Stephan N. Witt

Feist-Weiller Cancer CenterORCID 0000-0002-6462-2840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Nirjhar Mandal AloyiD· 2 shared Sahar ShekoohiiD· 2 shared Allison May ZhouiD· 1 shared Brandon HartmaniD· 1 shared Charles K. MeshuliD· 1 shared Christina M. CoughlaniD· 1 shared Cindy MooreiD· 1 shared Dillon BrownelliD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

Nirjhar Mandal AloyORCID

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4 papers

Recent·Most cited

Cancer BiologyHuman Molecular GeneticsPeer-reviewedJun 16, 2025

Alpha-synuclein modulates the positioning of endolysosomes in melanoma cells

Nirjhar Mandal Aloy, Maria Ericsson, Brandon Hartman, Stephan N. Witt

This study shows that alpha-synuclein modulates endolysosome positioning in melanoma cells, affecting invasion and migration by altering membrane protein levels and trafficking.

2 citations

humanelectronic health records

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Cell BiologyScience AdvancesPeer-reviewedApr 9, 2025

Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

Moriah R. Arnold, Gabriel M. Cohn, Kezia Catharina Oxe…·Vivek K. Unni

This study shows alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma cells, affecting genomic stability and cancer progression.

17 citations

humanDNA methylation

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Cancer BiologyScientific ReportsPeer-reviewedNov 7, 2024

Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response.

Santhanasabapathy Rajasekaran, Siyuan Cheng, Nithya Gajendran…·Stephan N. Witt

This study identifies α-synuclein's role in regulating inflammatory gene expression in melanoma cells through RNA sequencing and validation.

13 citations

humanbulk RNA-seq

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Cancer BiologyBiochemical and Biophysical Research CommunicationsPeer-reviewedAug 30, 2024

Possible regulation of the immune modulator tetraspanin CD81 by alpha-synuclein in melanoma

Nirjhar Mandal Aloy, Christina M. Coughlan, Michael W. Graner, Stephan N. Witt

The paper investigates how alpha-synuclein regulates CD81 in melanoma, showing their correlation with immune suppression and tumor progression.

5 citations

humanbulk RNA-seq

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