GeneticsbioRxivPreprint
A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data
DOI 10.1101/2024.02.01.578272
Author
Ke Xu
Yale UniversityORCID 0000-0002-6472-7052Unclaimed ORCID profile · follow to get notified of new preprints
Additional preprints under this name without ORCID
Biology Disciplines
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2019-2024 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship9 papers
Recent·Most cited
- GeneticsTranslational PsychiatryPeer-reviewed
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program
Youshu Cheng, Cecilia Dao, Hang Zhou…·Ke Xu
This study uses multi-trait analysis to identify novel genetic loci for smoking behaviors by leveraging alcohol use disorder GWAS data from the Million Veteran Program.
11 citations - Genetic & Genomic MedicinemedRxivPreprint
Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
Sylvanus Toikumo, Mariela V. Jennings, Benjamin K. Pham…·Sandra Sanchez‐Roige
This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.
8 citations - GenomicsbioRxivPreprint
A New Monocyte Epigenetic Clock Reveals Effects of Alcohol Consumption on Epigenetic Aging in Three Independent Cohorts
Xiaoyu Liang, Rajita Sinha, Amy C. Justice…·Ke Xu
This study develops a monocyte-based DNA methylation clock (MonoDNAmAge) and shows its nonlinear relationship with alcohol consumption across three cohorts.
DOI 10.1101/2021.03.22.436488 - Systems BiologyLife Science AlliancePeer-reviewed
Predicting cellular position in the Drosophila embryo from Single-Cell Transcriptomics data
Jovan Tanevski, Thin Nguyen, Buu Minh Thanh Truong…·Pablo Meyer
The paper predicts cellular positions in the Drosophila embryo using scRNA-seq data by benchmarking methods against spatially annotated genes.
26 citations - Genetic & Genomic MedicineJAMA PsychiatryPeer-reviewed
GWAS including 82,707 subjects identifies functional coding variant in OPRM1 gene associated with opioid use disorder
Hang Zhou, Christopher T. Rentsch, Zhongshan Cheng…·Veterans Affairs Million Veteran Program
185 citationstop 1% - GeneticsScientific ReportsPeer-reviewed
Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans
Ying Hu, Mohini Ranganathan, Chang Shu…·Ke Xu
This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.
- BioinformaticsMolecular PsychiatryPeer-reviewed
DNA Methylation Signature on Phosphatidylethanol, not Self-Reported Alcohol Consumption, Predicts Hazardous Alcohol Consumption in Two Distinct Populations
Xiaoyu Liang, Amy C. Justice, Kaku So‐Armah…·Ke Xu
The paper identifies a DNA methylation signature linked to phosphatidylethanol (PEth) that better predicts hazardous alcohol consumption than self-reported data in two populations.
30 citations - GeneticsbioRxivPreprint
Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)
Henry R. Kranzler, Hang Zhou, Rachel L. Kember…·On Behalf of the VA Million Veteran Program
This study identifies 18 genome-wide significant loci for alcohol consumption and AUD, finds genetic overlap but also divergence, and highlights the role of central nervous system cells.