BiophysicsiSciencePeer-reviewed
Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions
Xiaowei Jin, Jordan Rosenbohm, Eunju Kim…·Ruiguo Yang
This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.