Functions of C. elegans neurons from synaptic connectivity
The paper analyzes updated connectomes of C. elegans to identify modular structures and uncover new neuronal circuits and functions.
Author
Albert Einstein College of MedicineORCID 0000-0002-6511-9972Unclaimed ORCID profile · follow to get notified of new preprints
11 papers
Recent·Most cited
The paper analyzes updated connectomes of C. elegans to identify modular structures and uncover new neuronal circuits and functions.
Zhaoqian Su, Brian Griffin, Scott W. Emmons, Yinghao Wu
This paper develops a machine learning framework to predict interactions between cell surface proteins, achieving over 70% accuracy in human proteins and validating results against experimental data.
Naoko Sakai, Peter Sun, Byunghyuk Kim, Scott W. Emmons
The paper investigates the role of cell adhesion molecules in the differentiation and connectivity of ray sensory neurons in C. elegans, finding limited effects on axon trajectory and synaptic component accumulation in CAM mutants.
Rotem Ruach, Nir Ratner, Scott W. Emmons, Alon Zaslaver
The paper examines synaptic organization in C. elegans neurons and finds that synapses cluster along neurites, supporting local compartmentalized computations.
Laura Molina-García, Carla Lloret-Fernández, Steven J. Cook…·Richard J. Poole
The paper identifies a novel mechanism of sexual dimorphism in the nervous system through direct glia-to-neuron transdifferentiation during sexual maturation in C. elegans.
Christopher A. Brittin, Steven J. Cook, David H. Hall…·Netta Cohen
The paper presents a complete structure-function model of the C. elegans nerve ring by integrating volumetric reconstructions with synaptic and gap junctional connectomes, revealing modular organization and a reference core circuit.
Steven J. Cook, Charles M. Crouse, Eviatar Yemini…·Oliver Hobert
The paper re-evaluates the connectome of the C. elegans pharyngeal nervous system using serial EM reconstruction, revealing a more detailed structure and sensory-motor characteristics.
HoYong Jin, Scott W. Emmons, Byunghyuk Kim
The paper identifies that the rol-6 co-injection marker in C. elegans causes unintended GFP expression in male-specific neurons, highlighting its limitations for precise expression studies.
Christopher A. Brittin, Steven J. Cook, David H. Hall…·Netta Cohen
The paper reconstructs the C. elegans nerve ring at two time points and identifies three levels of wiring specificity, suggesting non-spatial factors contribute to synaptic and subcellular specificity.
María I. Lázaro‐Peña, Carlos A. Díaz-Balzac, Hannes E. Bülow, Scott W. Emmons
The paper shows heparan sulfate modifications are essential for synapse formation in C. elegans male mating circuits, with specific roles for 3-O sulfation and interactions between neurexin and neuroligin.