Author

Michelle A. Lay

University of ArizonaORCID 0000-0002-6522-4641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Jacob C. SchwartziD· 2 shared Valery F. Thompson· 2 shared Ajibola David Adelakun· 1 shared Austin A. Lipinski· 1 shared Ghassan MouneimneiD· 1 shared Jesse J. Altemus· 1 shared Marco Padilla‐RodrigueziD· 1 shared Mozani Zianti· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Jacob C. SchwartzORCID

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2 papers

Recent·Most cited

BiochemistryMolecular and Cellular BiologyPeer-reviewedAug 3, 2026

Global Profiling of Remodeled Subcellular Structures Due to Drug Treatment and Disease

Rachel A. Victor, Jesse J. Altemus, Michelle A. Lay…·Jacob C. Schwartz

The paper uses SEC-MS with crosslinking to analyze global changes in subcellular structures in Ewing sarcoma cell lines and after drug treatment, identifying effects on splicing, mitochondria, nucleoli, and peroxisomes.

DOI 10.1080/10985549.2026.2705873

humanproteomics

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BiochemistryBiopolymersPeer-reviewedMar 21, 2024

Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks

Michelle A. Lay, Valery F. Thompson, Ajibola David Adelakun, Jacob C. Schwartz

This study identifies how EWSR1 recognizes R-loops by binding DNA forks, revealing the role of its ZnF and RRM domains in specificity.

6 citations

experimental assay

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