Molecular BiologybioRxivPreprint
Pyruvate Kinase M Links Glucose Availability to Protein Synthesis
Nevraj S. Kejiou, Lena Ilan, Stefan Aigner…·Alexander F. Palazzo
The paper shows that PKM inhibits translation of 7% of the transcriptome under high glucose and pyruvate conditions by stalling ribosome elongation, linking glycolysis to protein synthesis and cell cycle regulation.
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