Alexander F. Palazzo

This study shows that RANBP2 mutations impair its nuclear envelope localization, leading to increased influenza replication and pro-inflammatory cytokine production.

The paper maps mutation patterns around human transcription start sites, revealing hypermutation and gBGC effects shaping their evolution.

The paper develops a mathematical model to predict isoform abundance distributions across species and genes, finding that factors beyond selection, like population size and cis-acting loci, significantly influence evolutionary outcomes.

The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.

The paper investigates the evolutionary forces shaping GC-content at gene transcriptional start sites, finding that recombination patterns drive GC-content changes in mammals.

The paper shows that protein-free mRNA induces stress granules via two G3BP1/2-dependent mechanisms, one involving PKR and eIF2 phosphorylation, and another independent of PKR and phospho-eIF2.

The paper identifies ZFC3H1 and U1-70K as factors promoting nuclear retention of mRNAs with 5' splice site motifs in nuclear speckles through a splicing-independent mechanism.

Profiling 192 subcellular markers by proximity-dependent biotinylation (BioID) in human HEK 293 cells maps 4,145 proteins across 32 compartments via 35,902 interactions, available with analysis tools at humancellmap.org.

This study shows RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1, which represses IL6 mRNA translation in ANE1.

The paper shows that TPR is necessary for nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes, with reporter constructs validating this role.

The paper shows that PKM inhibits translation of 7% of the transcriptome under high glucose and pyruvate conditions by stalling ribosome elongation, linking glycolysis to protein synthesis and cell cycle regulation.