Alfonso Schiavi

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

The paper identifies that lysosomal defects up-regulate cholesterol synthesis via mitochondrial respiratory chain interactions and Ca2+ retention, while mitochondrial defects down-regulate it.

This study identifies lutein as a potential therapeutic for mitochondrial dysfunction-induced neurodevelopmental defects in C. elegans by restoring neuroligin expression.

This study investigates how curcumin's anti-aging effects are mediated through AhR-dependent and -independent pathways in different contexts.