Alla Krasikova

This paper integrates single-cell Hi-C, RNA-seq, and microscopy to uncover how hypertranscription shapes lampbrush chromosome structure through transcription-dependent chromatin organization.

The paper identifies LL2R tandem repeats in chicken that form RNP condensates by recruiting splicing factors, revealing their role in nuclear compartment formation.

This paper identifies the full spectrum of maternal RNAs transcribed by chicken lampbrush chromosomes, including protein-coding genes, long non-coding RNAs, and small non-coding RNAs, and shows their role in early embryogenesis.

The paper compares A/B compartment distribution in chicken somatic cells with chromatin domains in lampbrush chromosomes, finding that B compartments correspond to compact chromomeres with repressive marks.

This study compares two single-cell Hi-C protocols, showing that whole-genome amplification introduces more artifacts and noise than PCR-based amplification.