Sarada Das

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

The paper investigates cellular responses to proteostasis impairments in yeast, finding that transcriptional responses often fail to restore proteostasis and that over-expression of alternative machineries can partially compensate for gene deletions.