Celia C. LaBranche

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

The paper identifies infant-transmitted HIV-1 variants that are neutralization-resistant to maternal plasma but sensitive to broadly neutralizing antibodies, suggesting maternal antibody responses select for these resistant variants during peripartum transmission.