Arnon Arazi

This study defines the single-cell landscape of Class II lupus nephritis and identifies fibroblast transcriptional programs and chronicity index as potential predictors of kidney outcomes.

The paper identifies spatially distinct macrophage-fibroblast interactions in lupus nephritis that drive myofibroblast heterogeneity and fibrosis.

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

The paper identifies distinct genetic mechanisms for early (nuclear) and late (cellular) RNA eQTL by comparing their genomic localization and functional effects across tissues.

This study identifies huTLR8's role in placental defects and pregnancy loss in lupus mice, showing its involvement in immune dysregulation and inflammation.

A single-cell atlas of blood and tissue samples from lupus nephritis patients and healthy controls identifies stromal and immune populations, including scar-associated macrophages, which correlate with disease activity.

The paper identifies three immunologically distinct groups in lupus nephritis patients based on blood immunophenotyping, correlating with histopathology, treatment response, and renal outcomes.

This paper establishes a protocol for preserving and analyzing single-cell transcriptomes from cryopreserved renal tissue and urine samples in lupus nephritis studies.