Ivana Yoseli Quiroga

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

The paper identifies 47 expression-modulating variants in AD-associated loci by analyzing their impact in immune cells under different inflammatory conditions.

This study shows TDP-43 pathology activates immune cells in ALS, linking it to immune dysfunction and suggesting immune monitoring as a diagnostic tool.

The paper identifies differential chromatin loops during megakaryocyte differentiation and shows their association with gene expression changes and histone modifications.

This study conducts the first GWAS on Alzheimer's disease in South American populations, identifying shared genetic risk factors with European populations.

The paper analyzes temporal changes in chromatin structure and gene expression during macrophage activation, finding a reciprocal relationship between loops and transcription.

The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.