Nicole R. Rutbeek

This study resolves the structure of bacteriophage T4 at different stages, revealing mechanisms of genome delivery and superinfection exclusion.

This study investigates the molecular mechanism of the Druantia anti-phage defense system, showing that DruH-E provides robust immunity and revealing its DNA unwinding and regulation by ATP.

This study identifies Prx as a multifunctional metabolic regulator in Streptococcus pyogenes that interacts with DNA-binding proteins and transcriptional regulators, contributing to phage genome maintenance and pathogenicity.

This paper shows that the phage protein paratox is intrinsically disordered in dilute solution but folds into a globular structure when bound to ComR or in the presence of stabilizing solutes.

This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.