Author
Western University of Health SciencesORCID 0000-0002-6900-3272Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Tharaka Darshana Wijerathne, Aneesh Chandrasekharan, Aashish Bhatt…·Jérôme J. Lacroix
This study shows Yoda1 agonizes PIEZO2 with efficacy similar to PIEZO1 but distinct effects on calcium influx and inactivation kinetics.
Gabriella A. Bertaccini, Ignasi Casanellas, Elizabeth L. Evans…·Medha M. Pathak
This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.
Shu Li, Tharaka Darshana Wijerathne, Aashish Bhatt…·Yun Luo
This study reveals how tension-induced structural changes in PIEZO2 channels lead to pore opening and ion conduction through dynamic conformational motions.
Tharaka Darshana Wijerathne, Aashish Bhatt, Wenjuan Jiang…·Jérôme J. Lacroix
This study shows that mammalian PIEZO1 and PIEZO2 channels rectify chloride currents inwardly, while sodium currents show little rectification, indicating voltage-dependent anion permeation.