BiochemistryNature BiotechnologyPeer-reviewed
Addressing the dNTP bottleneck restricting prime editing activity
Pengpeng Liu, Karthikeyan Ponnienselvan, Thomas Nyalile…·Scot A. Wolfe
This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.
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