NeuroscienceCell ReportsPeer-reviewed
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
Dan Dou, Erin M. Smith, Chantell S. Evans…·Erika L.F. Holzbaur
The paper shows that LRRK2 mutations disrupt autophagosome transport in neurons by creating a tug-of-war between dynein and kinesin motors, contributing to Parkinson's disease pathogenesis.
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