Author

Serah Kimani

University Health NetworkORCID 0000-0002-6960-3833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aiping DongiD· 2 shared C. H. ArrowsmithiD· 2 shared Dalia Barsyte-LovejoyiD· 2 shared Hong ZengiD· 2 shared Irene ChauiD· 2 shared Levon HalabelianiD· 2 shared Pegah Ghiabi· 2 shared Sumera PerveeniD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Aiping DongORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedNov 4, 2024

A resource to enable chemical biology and drug discovery of WDR Proteins

Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

28 citations

humanprotein structure

𝕏 PostBluesky

ImmunologyCommunications BiologyPeer-reviewedDec 16, 2023

Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor

Serah Kimani, Sumera Perveen, Magdalena M. Szewczyk…·Levon Halabelian

The paper investigates how a small-molecule inhibitor binds to and inactivates Cbl-b, revealing a structural mechanism that locks the protein in an inactive conformation.

42 citations

protein structureexperimental assay

𝕏 PostBluesky