Giovanni Blandino

This study evaluates genomic stability and evolution in cancer patient-derived organoids across 16 cancer types, finding higher genomic fidelity compared to patient-derived xenografts.

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

This study identifies circPVT1 as a regulator of metabolic pathways in breast cancer by sponging miR-33a-5p, leading to increased c-MYC and GLS1 activity and promoting tumorigenesis.

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

The paper compares gene expression in primary and metastatic tumors to their origin and target tissues, finding metastases more resemble target tissues and show reduced cancer hallmark activity.