Matthew C. Trudeau

This study evaluates the inhibition of hERG channels by verapamil using CiPA protocols, finding similar IC50 and Hill coefficient values across labs and demonstrating improved success rates with a revised protocol.

This study investigates whether the PAS domain remains attached to hERG channels during gating using patch-clamp fluorometry, finding that PAS remains associated despite mechanical and conformational changes.

This paper uses photo-crosslinking to study how the PAS domain of hERG channels affects channel kinetics and voltage dependence, showing state-dependent changes in activation and deactivation.