Egon Anderson Ozer

This study identifies 13 genes essential for extreme colistin resistance in Pseudomonas aeruginosa using transposon insertion sequencing and validates novel pathways contributing to resistance.

This study compares Galleria mellonella, epithelial cell cytotoxicity, and mouse models for measuring Pseudomonas aeruginosa virulence, finding G. mellonella correlates better with mouse results for population-level trends.

The paper identifies a novel mechanism of ceftolozane-tazobactam resistance in Pseudomonas aeruginosa mediated by an L2 β-lactamase gene, independent of its canonical regulator.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.

This paper develops a synthetic biology method to construct and reboot clinically-relevant Pseudomonas aeruginosa phages, demonstrating successful cloning, assembly, and rebooting in different bacterial strains.

This study identifies shared and strain-specific genes required for Klebsiella pneumoniae colonization using transposon sequencing in three clinical strains.

The paper identifies accessory genome deletions in modern Beijing lineage of Mycobacterium tuberculosis using pan-genome analysis and validates them with PCR, suggesting increased virulence.

This paper uses machine learning to predict the virulence of Pseudomonas aeruginosa isolates based on genomic data, achieving 75% accuracy using random forest models.