Som S. Chatterjee

This study shows that loss of GdpP function in Staphylococcus aureus leads to β-lactam antibiotic tolerance and increases mortality in infections, highlighting its clinical relevance in treatment failure.

This study identifies that mutations in PBP4 and GdpP synergistically confer high-level, broad-spectrum β-lactam resistance in mecA-deficient Staphylococcus aureus strains.