Author

Sung Woo Cho

Weill Cornell MedicineORCID 0000-0002-7206-798XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hossam NadaiD· 2 shared Moustafa Tarek GabriD· 2 shared Farida El Gaamouch· 1 shared Katarzyna KuncewicziD· 1 shared Laura Calvo‐BarreiroiD· 1 shared Saurabh UpadhyayiD· 1 shared Shaoren Yuan· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Hossam NadaORCID

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2 papers

Recent·Most cited

NeuroscienceEuropean Journal of Medicinal ChemistryPeer-reviewedNov 15, 2025

TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization

Hossam Nada, Shaoren Yuan, Farida El Gaamouch…·Moustafa Tarek Gabr

This paper identifies first-in-class small molecule agonists of TREM2 through DEL screening, validates their binding and function, and suggests a novel activation mechanism.

11 citations

experimental assaydrug response / drug discovery

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Pharmacology & ToxicologybioRxivPreprintOct 6, 2025

Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation

Saurabh Upadhyay, Hossam Nada, Sung Woo Cho, Moustafa Tarek Gabr

This study identifies BPU11, a small molecule CD28 antagonist that disrupts CD28-B7 interactions and suppresses T-cell activation, offering a new approach to immune checkpoint blockade.

1 citation

humanproteomics

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