Jessica Lacoste

This study shows tioxazafen is bioactivated by cytochrome P450s into a proteasome disruptor, leading to toxicity in nematodes and potential human skin reactions.

The paper identifies cytosolic mutant proteins degraded by the proteasome and shows DNAJA2 stabilizes some mutants while being dispensable for wild-type proteins.

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

The paper identifies potent protein degraders and stabilizers using proteome-scale induced proximity screens and shows they outperform existing E3 ligases.