Author

Stephen D. C. Griffin

University of LeedsORCID 0000-0002-7233-5243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Adel SamsoniD· 2 shared Amy Moran· 2 shared Russell Hughes· 2 shared Alan A. MelcheriD· 1 shared Andrew MacdonaldiD· 1 shared Elizabeth J. IlettiD· 1 shared Elizabeth S. AppletoniD· 1 shared Gemma SwinscoeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Adel SamsonORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 18, 2025

Oncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity

Samantha Yolotzin García Cárdenas, Gemma Swinscoe, Amy Moran…·Stephen D. C. Griffin

This paper shows that oncolytic Reovirus can eliminate SARS-CoV-2 in lung cells without causing toxicity by enhancing innate antiviral responses.

DOI 10.64898/2025.12.17.694833

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 23, 2024

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

Russell Hughes, Amy Moran, Karen J. Scott…·Stephen D. C. Griffin

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky