Author

Alex D. Doan

Fred Hutch Cancer CenterORCID 0000-0002-7247-2256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

David P MacPhersoniD· 1 shared David SokoloviD· 1 shared Eric Zheng· 1 shared Kristian DavidseniD· 1 shared Lucas B. SullivaniD· 1 shared Madeleine L. HartiD· 1 shared Serwah Danquah· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

David P MacPhersonORCID

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1 paper

Recent·Most cited

Cell BiologyNature MetabolismPeer-reviewedMay 4, 2026

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase

Madeleine L. Hart, David Sokolov, Serwah Danquah…·Lucas B. Sullivan

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

8 citationstop 1%

metabolomicsexperimental assay

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