David Sokolov

This study identifies two adaptive mechanisms in SDH-deficient cancer cells to overcome aspartate limitation and improve proliferative fitness.

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

This study shows that NMNAT1 deletion in developing murine retina causes severe photoreceptor and inner retinal neuron degeneration through multiple cell death pathways and metabolic disruptions.