Zeno Lavagnino

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

The paper shows that micronuclei formation during chromatin bridge resolution in prostate cancer cells leads to emerin pauperization from the nuclear envelope, enhancing cell migration and invasiveness.

The paper shows that a short translational ramp in mRNA's first 5 codons significantly affects protein synthesis efficiency, independent of tRNA abundance or initiation efficiency.