Tomasz Wenta

This study identifies β4-integrins as critical for maintaining nuclear mechanics and integrity in prostate cancer, linking cell-ECM adhesion to genome stability and patient survival.

The paper identifies a novel BACH1 transcriptional signature in lung cancer cells, validated across multiple cell lines, and demonstrates its utility in detecting BACH1 perturbations and identifying inhibitors.

The paper shows that micronuclei formation during chromatin bridge resolution in prostate cancer cells leads to emerin pauperization from the nuclear envelope, enhancing cell migration and invasiveness.