Sylvain Tollis

This paper introduces a functionalist oncology framework using edge-weighted digraphs to model AML treatment dynamics and evaluate drug combinations, including SAMHD1 inhibitors.

The paper uses single cell transcriptomics and mathematical modeling to show how cyclin D, cyclin E, and CDKN sub-modules in the G1/S network drive distinct proliferation trajectories in hematopoietic cells.

This study shows that Swi4-dependent transcription couples cell size to cell cycle commitment in budding yeast by regulating Swi4 accumulation and Start timing.