Khaled Alganem

This study shows that low-dose developmental exposure to deltamethrin disrupts molecular pathways related to circadian rhythms and MAP kinase in mouse brains, linking it to ADHD-like behaviors.

The paper identifies Egr3-dependent genes in mice hippocampi after ECS, finding genes related to DNA damage response and schizophrenia.

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

The paper identifies five core protein kinases in neurons and astrocytes from familial AD patient iPSCs and examines their enriched pathways using a combination of experimental and in-silico approaches.

KRSA predicts differential kinase activity from kinome array data by analyzing phosphorylation differences and comparing results to gene expression databases.

Kaleidoscope is a web application that provides access to omics databases and tools for in silico hypothesis exploration, demonstrating its use with DISC1 gene analysis across multiple datasets.

The paper identifies lamina-specific gene expression changes in pyramidal neurons from schizophrenia patients compared to controls, highlighting immune and synaptic pathway disruptions.

This paper reviews signature-based in silico approaches for drug repurposing in CNS disorders, integrating data science platforms to improve clinical relevance and address regulatory and knowledge challenges.

The paper examines protein expression levels of prenyltransferase subunits in schizophrenia patients and finds decreased expression of FNTA, PGGT1B, and RABGGTB in the dorsolateral prefrontal cortex.

The paper identifies PPAR agonists as potential treatments for schizophrenia by analyzing bioenergetic changes in the DLPFC using bioinformatics and experimental validation.